# reactome-mcp

> Use this tool when you need to interact with biological pathway data, such as searching or analyzing gene sets, and require programmatic access to the Reactome database. It solves problems related to pathway analysis, data export, and enrichment analysis, accepting inputs like gene identifiers and pathway names, and producing outputs like SBML/SBGN models and enrichment results. Ideal for use cases involving systems biology, bioinformatics, and network analysis.

Canonical page: https://skillsregistry.net/skills/tc2fh-reactome-mcp  
JSON: https://api.skillsregistry.net/v1/skills/tc2fh-reactome-mcp

## Description

Enables coding agents to interact with the Reactome pathway database, including search, lookup, hierarchy traversal, SBML/SBGN export, and gene-set enrichment analysis.

## Trust

- **Trust score (0–1):** 0.69
- **Verification tier:** scanned
- **Last scanned:** 2026-08-30

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** mcp-remote
- **Runtime environment:** api
- **Category:** database
- **Updated:** 2026-08-30

## Source

- **Source listing:** [Glama](https://glama.ai/mcp/servers/s7kgzv9r5p)
- **Repository:** <https://github.com/tc2fh/reactome-mcp>

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "tc2fh-reactome-mcp"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/tc2fh-reactome-mcp` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/tc2fh-reactome-mcp/pull`

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SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt