# mcp-ncbi-variation

> mcp-ncbi-variation — pipeworx-io-mcp-ncbi-variation. Use this tool when you need to normalize human genetic variants or access dbSNP refSNP records, as it provides HGVS/SPDI/rsID normalization and retrieval of variant information from NCBI Variation Services, accepting variant identifiers as input and returning standardized representations as output. This tool solves problems related to variant data consistency and integration, facilitating accurate analysis and comparison of genetic variants. It is particularly useful in bioinformatics and genomics research contexts where data standardization is crucial.

Canonical page: https://skillsregistry.net/skills/pipeworx-io-mcp-ncbi-variation  
JSON: https://api.skillsregistry.net/v1/skills/pipeworx-io-mcp-ncbi-variation

## Description

dbSNP refSNP records and HGVS/SPDI/rsID normalization for human genetic variants, from NCBI Variation Services.

## Trust

- **Trust score (0–1):** 0.99
- **Verification tier:** verified
- **Last scanned:** 2026-09-28

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** container
- **Runtime environment:** vm
- **License:** MIT
- **Updated:** 2026-09-28

## Source

- **Source listing:** [GitHub](https://github.com/pipeworx-io/mcp-ncbi-variation)

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "pipeworx-io-mcp-ncbi-variation"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/pipeworx-io-mcp-ncbi-variation` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/pipeworx-io-mcp-ncbi-variation/pull`

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SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt