# GeneChat MCP Server

> Use this tool when you need to analyze whole-genome VCF files and query pharmacogenomics, disease risk, and carrier status through natural language. It annotates genetic data and provides insights on genetic variations, solving problems in personalized medicine and genetic research. The GeneChat MCP Server takes VCF files as input and outputs annotated genetic data, making it ideal for use cases in genetic counseling, research, and precision medicine.

Canonical page: https://skillsregistry.net/skills/natecostello-genechat-mcp  
JSON: https://api.skillsregistry.net/v1/skills/natecostello-genechat-mcp

## Description

A local-first MCP server that annotates whole-genome VCF files and lets you query pharmacogenomics, disease risk, and carrier status through natural language.

## Trust

- **Trust score (0–1):** 0.49
- **Verification tier:** scanned
- **Last scanned:** 2026-08-31

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** mcp-remote
- **Runtime environment:** api
- **Category:** file-system
- **Updated:** 2026-08-31

## Source

- **Source listing:** [Glama](https://glama.ai/mcp/servers/g2irug2rz4)
- **Repository:** <https://github.com/natecostello/genechat-mcp>

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "natecostello-genechat-mcp"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/natecostello-genechat-mcp` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/natecostello-genechat-mcp/pull`

---
SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt