# SPIRED-Stab MCP

> Use this tool when you need to predict protein stability and analyze mutations, as it enables the estimation of $\Delta\Delta$G and $\Delta$Tm values using a deep learning model, accepting protein sequences as input and producing stability predictions as output, ideal for protein engineering and design applications. It supports both single variant analysis and batch processing, streamlining mutation analysis workflows. This tool is particularly useful in biochemistry and molecular biology research contexts.

Canonical page: https://skillsregistry.net/skills/macromnex-spired-stab-mcp  
JSON: https://api.skillsregistry.net/v1/skills/macromnex-spired-stab-mcp

## Description

Enables protein stability prediction ($DeltaDelta$G and $Delta$Tm) and systematic mutation analysis using the SPIRED-Stab deep learning model. It supports single variant analysis, batch processing, and job monitoring via Docker-based inference.

## Trust

- **Trust score (0–1):** 0.65
- **Verification tier:** scanned
- **Last scanned:** 2026-09-19

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** mcp-remote
- **Runtime environment:** api
- **Category:** cloud-infra
- **Updated:** 2026-09-19

## Source

- **Source listing:** [Glama](https://glama.ai/mcp/servers/ny857su5sv)
- **Repository:** <https://github.com/MacromNex/spired_stab_mcp>

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "macromnex-spired-stab-mcp"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/macromnex-spired-stab-mcp` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/macromnex-spired-stab-mcp/pull`

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SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt