# OpenCRAVAT

> Use this tool when you need to annotate genetic variants with a comprehensive set of data, solving problems in genomic analysis and interpretation. OpenCRAVAT takes in genetic change information, such as rsID, CAid, and HGVS notation, and outputs annotated variants with detailed information on protein changes. It is ideal for use in genomics research and clinical applications where accurate variant interpretation is crucial.

Canonical page: https://skillsregistry.net/skills/karchinlab-oc-mcp  
JSON: https://api.skillsregistry.net/v1/skills/karchinlab-oc-mcp

## Description

Annotate variants by with a deep and rich set of data. Can annotate: genetic change, rsID, CAid, HGVS (g./c./p.), protein change.

## Trust

- **Trust score (0–1):** 0.97
- **Verification tier:** verified
- **Last scanned:** 2026-09-28

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** mcp-remote
- **Runtime environment:** api
- **Category:** other
- **Updated:** 2026-09-28

## Source

- **Source listing:** [Glama](https://glama.ai/mcp/servers/tf21cjvjtk)
- **Repository:** <https://github.com/KarchinLab/oc-mcp>

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "karchinlab-oc-mcp"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/karchinlab-oc-mcp` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/karchinlab-oc-mcp/pull`

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SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt