# metadome-link

> Use this tool when you need to analyze the effects of genetic variants on human transcripts, such as querying per-residue missense tolerance and identifying constrained regions. It solves problems related to understanding the impact of mutations on protein function and structure by providing annotations and variant counts. The tool takes transcript identifiers as input and outputs tolerance landscapes and constrained region annotations.

Canonical page: https://skillsregistry.net/skills/berntpopp-metadome-link  
JSON: https://api.skillsregistry.net/v1/skills/berntpopp-metadome-link

## Description

Enables querying of per-residue missense tolerance, Pfam domain annotations, and variant counts for human transcripts by wrapping the MetaDome web service. Provides MCP tools for resolving transcripts, requesting tolerance landscapes, and identifying constrained regions.

## Trust

- **Trust score (0–1):** 0.67
- **Verification tier:** scanned
- **Last scanned:** 2026-08-31

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** mcp-remote
- **Runtime environment:** api
- **Category:** other
- **Updated:** 2026-08-31

## Source

- **Source listing:** [Glama](https://glama.ai/mcp/servers/odl79u4zvk)
- **Repository:** <https://github.com/berntpopp/metadome-link>

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "berntpopp-metadome-link"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/berntpopp-metadome-link` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/berntpopp-metadome-link/pull`

---
SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt