# clinvar-link

> clinvar-link — berntpopp-clinvar-link. Use this tool when you need to access variant clinical significance and gene-level classifications from NCBI ClinVar, providing a local SQLite index for efficient querying and retrieval of clinical significance data. It solves problems related to variant interpretation and gene classification, offering a reliable alternative to the eUtils API. Ideal for use cases requiring rapid and offline access to ClinVar data, with input capabilities via git and output in a structured format.

Canonical page: https://skillsregistry.net/skills/berntpopp-clinvar-link  
JSON: https://api.skillsregistry.net/v1/skills/berntpopp-clinvar-link

## Description

MCP server for NCBI ClinVar: variant clinical significance and gene-level classifications, served from a local SQLite index built from the ClinVar weekly bulk release — not the eUtils API.

## Trust

- **Trust score (0–1):** 0.50
- **Verification tier:** unverified

## Facts

- **Version:** 1.0.0
- **Skill type:** atomic
- **Execution layer:** container
- **Runtime environment:** vm
- **License:** MIT
- **Updated:** 2026-09-28

## Source

- **Source listing:** [GitHub](https://github.com/berntpopp/clinvar-link)

## Use it

Resolve this record through the SkillsRegistry MCP server (no auth, read-only):

```
claude mcp add --transport http --scope user skillsregistry https://api.skillsregistry.net/mcp
```

```json
{
  "jsonrpc": "2.0",
  "id": 1,
  "method": "tools/call",
  "params": {
    "name": "get_skill",
    "arguments": {
      "slug": "berntpopp-clinvar-link"
    }
  }
}
```

REST: `GET https://api.skillsregistry.net/v1/skills/berntpopp-clinvar-link` · pull for local use: `GET https://api.skillsregistry.net/v1/skills/berntpopp-clinvar-link/pull`

---
SkillsRegistry indexes agent skills from public registries and GitHub. Skills we have analysed are scanned with Circle-IR and scored on six dimensions; each listing states its scan coverage. More: https://skillsregistry.net/llms.txt